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Insights into the Mechanism of Bile Salt Aggregates Forming in a PEGylated Amphiphilic Polymer/Bile Salt Mixed Micelle
Author(s) -
Tan Qinggang,
Bie Min,
Wang Zihao,
Chu Yanyan,
Tao Susu,
Xu Xiaoyan,
Liu Yingbin
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800382
Subject(s) - micelle , amphiphile , copolymer , chemistry , dimer , drug delivery , peg ratio , polyethylene glycol , salt (chemistry) , polymer chemistry , polymer , chemical engineering , materials science , organic chemistry , aqueous solution , finance , economics , engineering
Tailoring the structure of core‐shell interface of amphiphilic copolymer micelles provides a potential to mediate the drug release from micelles. Here, bile salts were used to alter the molecular geometry of core‐shell structured amphiphilic copolymer micelles. With the different sodium deoxycholate (NaDC) addtions in the methoxy polyethylene glycol‐poly(D,L‐lactic acid) (MPEG‐PDLLA) solutions, the NaDC molecule could form different deoxycholic acid (DCA) dimers in the core and shell of micelles. A face‐to‐face DCA dimer structure could form and insert into the core of micelles when a small NaDC addition. This dimer could accelerate the drug release. At a high NaDC addition, a new back‐to‐back DCA dimer could form in the PEG shell region that would reduce the rate of drug release. The results obtained provide fundamental insights into the role of bile salts in adjusting the drug release of amphiphilic copolymer micelles and demonstrate the future potential for controlled drug‐delivery applications.