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Synthesis of Naphthalimine‐derived Dye and Its Applications in Fluorescent Imaging and Dyeing Surgical Suture Materials
Author(s) -
Xiong Xiaoqing,
Zhi Weiru,
Yan Jun,
Song Wenjing,
Du Hui,
Zhao Hongjuan,
Li Feixia,
Song Fengling,
Sun Yanfeng,
Zheng Laijiu
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800342
Subject(s) - indometacin , fluorescence , dyeing , in vivo , chemistry , photochemistry , materials science , optics , in vitro , organic chemistry , biochemistry , biology , microbiology and biotechnology , prostaglandin endoperoxide synthase , physics , enzyme inhibitor
In this study, NP‐indometacin , which was based on the two‐photon naphthalimine, was designed and synthesized. The anti‐inflammatory material indometacin was introduced into NP‐indometacin so that the toxicity of this fluorescent dye was reduced when applied to living organisms. NP‐indometacin had high fluorescence quantum efficiency (0.98 in DMSO), a large Stokes shift (>77 nm) and feasible two‐photon action cross section (45 GM in DMSO). NP‐indometacin was utilized for the fluorescence imaging of living cells, and the high cell viability rate (>80%) indicated that this material had low toxicity in living organisms. NP‐indometacin was used to dye absorbable collagen surgical suture and constructed fluorescent surgical suture. It was found by one‐ and two‐photon fluorescence imaging that NP‐indometacin distributed uniformly both outside and inside the sutures. Therefore, the straightforward synthesis of NP‐indometacin and the wide availability of its constituents mean that it could both be highly useful for the observation of the healing of wounds and as a fluorescent warning material that is used in vivo .