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Enantioselective Separation of Racemic Tryptophan with Sonochemically Prepared Egg Albumin Microspheres
Author(s) -
Mutalikdesai Amruta,
Zoabi Amani,
Kumar Vijay Bhooshan,
AbuReziq Raed,
Hassner Alfred,
Gedanken Aharon
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800337
Subject(s) - tryptophan , enantiomer , sonication , chemistry , enantioselective synthesis , microsphere , amino acid , aqueous solution , bovine serum albumin , enantiomeric excess , resolution (logic) , chromatography , organic chemistry , chemical engineering , catalysis , biochemistry , engineering , artificial intelligence , computer science
New approaches for chiral resolution are gaining importance and are of economic interest for the development of pharmaceuticals, agrochemicals, chiral sensors and food additives. Herein we disclose the first examples in which sonochemically prepared egg albumin microspheres (EAMs) were used for chiral resolution of an amino acid. When EAMs were in contact with an aqueous solution of racemic tryptophan (Trp) they selectively interacted with L‐Trp leading to 94% enantiomeric excess (ee) of D‐Trp. In a control experiment in which the egg protein, without applying ultrasonic waves to form microspheres, was dissolved and exposed to racemic Trp, no chiral resolution was observed. The effects of temperature and concentration were studied in detail. These preliminary results show that EAMs produced by sonication may provide a simple, cost‐effective an unconventional way to chiral separation of racemic amino acids.