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Click Chemistry Inspired Design, Synthesis and Molecular Docking Studies of Coumarin, Quinolinone Linked 1,2,3‐Triazoles as Promising Anti‐Microbial Agents
Author(s) -
Savanur Hemantkumar M.,
Naik Krish.,
Ganapathi Shailaja M.,
Kim Kang Min,
Kalkhambkar Rajesh G.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800319
Subject(s) - coumarin , yeast , chemistry , docking (animal) , bioassay , stereochemistry , triazole , biological activity , combinatorial chemistry , organic chemistry , in vitro , biochemistry , biology , medicine , nursing , genetics
A series of new coumarin, quinolinone and benzyl linked 1,2,3‐triazole derivatives have been synthesized and screened for their anti‐bacterial and anti‐fungal activities. Results of bioassay indicate that, compounds containing chloro and methoxy substituents in coumarin ( 6 j ), chloro substitution in quinolinone ( 7 g ) and 3‐chloro benzyl analogue ( 8 f ) exhibit excellent anti‐bacterial activities. The results of anti‐fungal activities also reveal that methoxy and chloro substituted coumarins ( 6 e and 6 j ) were highly active against yeast strains. In addition, chloro and methyl substituted coumarins ( 6 h and 6 i ) were also exhibited excellent activity. Further, methyl substituted quinolinone with chloro substituted coumarin ( 7 f ) was found to highly active against yeast fungi and filamentous strain A.niger . It is evident from the results obtained and SAR studies that electron withdrawing or donating character of the substituents do not seem to be a major factor in increasing or decreasing anti‐microbial activity.