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Studies on DNA Interaction with 2(3),9(10), 16(17), 23(24)‐Tetrakis 2((4‐Phenoxyphenyl) Diazeylbenzoic acid)phthalocyaninato Zinc (II) Compound
Author(s) -
Arslantas Ali,
Agirtas Mehmet Salih
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800172
Subject(s) - intercalation (chemistry) , zinc , chemistry , titration , buffer solution , dna , ligand (biochemistry) , phthalocyanine , inorganic chemistry , absorption (acoustics) , fluorescence , cyclic voltammetry , nuclear chemistry , crystallography , organic chemistry , materials science , electrochemistry , receptor , biochemistry , physics , electrode , quantum mechanics , composite material
In this study, 2(3), 9(10), 16(17), 23(24)‐tetrakis 2((4‐phenoxyphenyl) diazeylbenzoic acid)phthalocyaninato zinc (II) compound was chosen to study DNA binding activities. The binding activities of zinc (II) phthalocyanine compound bearing 2(3),9(10), 16(17), 23(24)‐tetrakis 2((4‐Phenoxyphenyl) diazeylbenzoic acid) ligand with Calf Thymus (CT)‐DNA was investigated using absorption titration, fluorescence spectroscopy, cyclic voltammetry and thermal melting profile in a Tris‐HCl buffer system at pH 7.0. In addition to these methods, gel electrophoresis and viscosity measurements were also carried out to determine DNA binding activities with compound 6 in a buffer solution. The results indicated that compound 6 interacts with CT‐DNA through partial intercalation binding mode.