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New 3’‐Triazolyl‐5’‐aryl‐chalcogenothymidine: Synthesis and Anti‐oxidant and Antiproliferative Bladder Carcinoma (5637) Activity
Author(s) -
Munchen Taiana S.,
Sonego Mariana S.,
de Souza Diego,
Dornelles Luciano,
Seixas Fabiana K.,
Collares Tiago,
Piccoli Bruna C.,
da Silva Fernanda D'Ávila,
da Rocha João Batista T.,
Quoos Natália,
Rodrigues Oscar E. D.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800156
Subject(s) - selenium , aryl , tellurium , antioxidant , cytotoxicity , sulfur , chemistry , combinatorial chemistry , biological activity , stereochemistry , organic chemistry , in vitro , biochemistry , alkyl
This article describes the synthesis and characterization of new 3’‐triazolyl‐5’‐aryl‐chalcogenothimidyne derivatives. Sulfur, selenium, and tellurium nucleosides were prepared from commercial zidovudine, using a linear synthetic strategy affording these compounds in good yields. The respective molecules were evaluated for cytotoxicity in bladder carcinoma 5637 cells and as an antioxidant agent, showing a linear dependence on the chalcogenium atom for both biological approaches. Tellurium was the most active element, followed by selenium and sulfur.