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Ru(Cl)‐Salen Complex: Solvent Selective Homogeneous Catalyst for One‐Pot Synthesis of Nitriles and Amides
Author(s) -
Borase Pravin N.,
Thale Pranila B.,
Shankarling Ganapati. S.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800121
Subject(s) - nitrile , catalysis , chemistry , amide , solvent , nitrile hydratase , homogeneous catalysis , aqueous solution , substrate (aquarium) , combinatorial chemistry , organic chemistry , selectivity , oceanography , geology
Abstract An efficient protocol for direct transformation of aldehydes into of nitrile and amide derivatives using Ru(Cl)‐salen complex as a solvent selective homogeneous catalyst is developed. The catalyst has also been explored for hydration of nitrile to synthesize the primary amides in an aqueous medium. Additionally, a mechanistic pathway for the dehydration of aldoxime to nitrile and hydration of nitrile to amide was studied using gas chromatography. The catalyst has been fully characterized by using spectroscopic techniques such as IR spectroscopy, MALDI‐TOF mass analysis and 1 H NMR technique. A simple work up procedure, lower catalyst to substrate ratio, and good to excellent yields of the products, higher turnover number and turnover frequency makes the protocol more advantageous and feasible.