Enantioselective Addition of Cyanide to CF 3 ‐Substituted Alkylidenemalonates: Construction of Trifluoromethylated All‐Carbon Quaternary Stereocenters | Zendy

Jakhar Ajay | Zendy; Nazish Mohd | Zendy; Gupta Naveen | Zendy; Khan Noorul H. | Zendy; Kureshy Rukhsana I. | Zendy

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Enantioselective Addition of Cyanide to CF 3 ‐Substituted Alkylidenemalonates: Construction of Trifluoromethylated All‐Carbon Quaternary Stereocenters

Author(s) -

Jakhar Ajay,

Nazish Mohd,

Gupta Naveen,

Khan Noorul H.,

Kureshy Rukhsana I.

Publication year - 2018

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201800113

Subject(s) - stereocenter , enantioselective synthesis , cyanation , chemistry , cinchona , cyanide , nitrile , chirality (physics) , yield (engineering) , organic chemistry , stereochemistry , catalysis , medicinal chemistry , materials science , chiral symmetry breaking , physics , quantum mechanics , quark , nambu–jona lasinio model , metallurgy

The construction of a new class of chiral organofluorine compounds with an all‐carbon stereocenter bearing a CF 3 group was disclosed. The cinchona alkaloid based phase transfer catalyzed asymmetric conjugated cyanation of CF 3 substituted alkylidene malonates have been developed. The nitrile products were achieved in excellent yield with good enantioselectivity. The chirality of product increased up to 98% by recrystallization.

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