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Highly Oxygenated 11‐Keto‐β‐boswellic Acid Analogues and Their Anti‐Inflammatory Potential
Author(s) -
Majeed Muhammed,
Nagabhushanam Kalyanam,
Bani Sarang,
Choudhury Ambar K.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800094
Subject(s) - proinflammatory cytokine , chemistry , tumor necrosis factor alpha , stereochemistry , cytokine , biochemistry , inflammation , biology , immunology
Novel 9‐α‐hydroxy‐11‐keto‐β‐boswellic acid analogues constituted with versatile functionality at ring A have been synthesized for the first time from 3‐ O ‐acetyl‐11‐keto β‐boswellic acid (AKBBA) and described herein. The anti‐malarial potential of endoperoxide benzyl ester was evaluated against the malarial parasite and exhibited reasonable anti‐malarial activity (2 μM). Anti‐inflammatory potential of all new analogues was examined against proinflammatory cytokine, Tumor Necrosis Factor‐alpha (TNF‐α) and one of them was found to possess similar activity as that of AKBBA.