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Aqueous Chloroplatinic Acid: A Green, Chemoselective and Reusable Catalyst for the Deprotection of Acetals, Ketals, Dioxolanes and Oxathiolanes
Author(s) -
Anil Seegehalli M,
Vinayaka Ajjampura C,
Rajeev Narasimhamurthy,
Swaroop Toreshettahally R,
Mallesha Ningegowda,
Rangappa Kanchugarakoppal S,
Sadashiva Maralinganadoddi P
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800032
Subject(s) - chloroplatinic acid , catalysis , chemistry , diol , selectivity , aqueous solution , organic chemistry , yield (engineering) , combinatorial chemistry , materials science , platinum , metallurgy
Aqueous chloroplatinic acid (H 2 PtCl 6 ) as an effective catalyst for the deprotection of acetals, ketals, 1,3‐dioxolanes and 1,3‐oxathiolanes to the corresponding carbonyl compounds in 56–99% yield has been reported. In addition, the catalyst has high‐selectivity in cleaving vicinol diol protection, yielding mono‐protected diols from di‐protected diols as a product. The present deprotection method is novel, chemoselective and offers broad functional group tolerance with short reaction time. Besides, the reaction protocol can be accomplished at ambient temperature and the catalyst is reusable.