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Access to 3‐Aroylchromanones from Dibenzoylmethanes via an Iron‐Catalyzed α‐Methylenation Reaction
Author(s) -
Gouveia Ana Paula A.,
Taylor Jason Guy
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800029
Subject(s) - catalysis , dimethylacetamide , intramolecular force , tandem , chemistry , reaction conditions , combinatorial chemistry , cascade reaction , michael reaction , organic chemistry , medicinal chemistry , materials science , solvent , composite material
A simple and straightforward synthesis of 3‐aroylchromanones based on a tandem iron catalyzed α‐methylenation – intramolecular oxy‐Michael addition reaction of dibenzoylmethanes with N,N ‐dimethylacetamide is described. The reaction employs FeCl 3 as catalyst under aerobic conditions to afford the corresponding 3‐aroylchromanones and tolerates a variety of substituents on both aromatic rings.
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