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Indium‐Mediated Domino Allylation‐Lactonisation Approach: Diastereoselective Synthesis of β‐Carboline C‐3 Tethered α‐Methylene γ‐Butyrolactones
Author(s) -
Singh Dharmender,
Hazra Chinmoy K.,
Malakar Chandi C.,
Pandey Satyendra K.,
Kaith B. S.,
Singh Virender
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201800006
Subject(s) - domino , chemistry , methylene , tandem , intramolecular force , stereochemistry , indium , cascade reaction , combinatorial chemistry , medicinal chemistry , catalysis , organic chemistry , materials science , composite material
A facile and convenient tandem approach has been devised towards the diastereoselective synthesis of β‐carboline C‐3 tethered α‐methylene γ‐butyrolactones via indium‐promoted Barbier Type allylation reaction followed by in situ intramolecular lactonisation protocol. Interestingly, no additive was required for this transformation and the products were obtained with syn stereochemistry.