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Silica‐Impregnated Polyphosphoric Acid Catalyzed an Eco‐Friendly Rapid Synthesis of Functionalized Tetrahydroquinolines and Quinazolin‐4‐ones in Water
Author(s) -
Ansari Mohd. Imran,
Hussain Mohd. Kamil,
Hajela K.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201703192
Subject(s) - catalysis , environmentally friendly , chemistry , substrate (aquarium) , combinatorial chemistry , metal , organic chemistry , ecology , oceanography , biology , geology
A metal‐free, mild, eco‐friendly and efficient method has been developed for the synthesis of functionalized tetrahydroquinolines, quinazolin‐4(1H)‐ones and quinazolin‐4(3H)‐ones using metal‐free and economically viable heterogeneous catalyst PPA‐SiO 2 in water preferentially forming cis ‐isomer. Both electron withdrawing and electron donating groups were found to be well tolerated and isolated products were obtained in good yields. Cis‐isomer was predominant in case of electron donating substrate in water.