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Copper‐Catalyzed Click Synthesis of Novel 1,2,3‐Triazole‐Linked Pyrimidines
Author(s) -
Bakherad Mohammad,
Rezaeimanesh Fatemeh,
NasrIsfahani Hossein
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201703088
Subject(s) - cycloaddition , click chemistry , bacillus subtilis , chemistry , combinatorial chemistry , triazole , propargyl , azide , micrococcus luteus , catalysis , aryl , alkyne , 1,2,3 triazole , copper , pseudomonas aeruginosa , ligand (biochemistry) , organic chemistry , bacteria , biology , biochemistry , escherichia coli , receptor , alkyl , gene , genetics
A series of novel 1,2,3‐triazole‐functionalized pyrimidines were prepared by the reaction of 4‐propargyl‐substituted‐5‐bromo‐2‐chloro‐6‐methylpyrimidine with aryl azides via copper‐catalyzed azide‐alkyne cycloaddition reactions in the presence of phenylenediamine, as a ligand. This method offers the advantages of mild experimental conditions, operational simplicity, and good to high reaction yields. Furthermore, the synthesized compounds were screened against the three bacterial strains Micrococcus luteus, Pseudomonas aeruginosa, and Bacillus subtilis.