Synthesis and DNA‐Binding Studies of A New Cyclic Dimeric Symmetrical Pseudo‐Turn Mimetic | Zendy

Banerji Biswadip | Zendy; Chatterjee Satadru | Zendy; Killi Sunil Kumar | Zendy; Srinivas D. | Zendy; Prodhan Chandraday | Zendy; Katarkar Atul | Zendy; Chaudhuri Keya | Zendy

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Synthesis and DNA‐Binding Studies of A New Cyclic Dimeric Symmetrical Pseudo‐Turn Mimetic

Author(s) -

Banerji Biswadip,

Chatterjee Satadru,

Killi Sunil Kumar,

Srinivas D.,

Prodhan Chandraday,

Katarkar Atul,

Chaudhuri Keya

Publication year - 2018

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201703062

Subject(s) - intramolecular force , minor groove , turn (biochemistry) , chemistry , dna , stereochemistry , groove (engineering) , dapi , molecule , hydrogen bond , crystallography , materials science , biochemistry , organic chemistry , apoptosis , metallurgy

A new dimeric cyclic 24 member symmetrical turn analogue was synthesized efficiently by an intramolecular Heck reaction. This facile reaction has produced selectively a single dimeric product having two sets of intramolecular hydrogen bonds (IHB) at the two ends of it. Different experimental studies have unambiguously proved the presence of a pseudo‐turn like structure. Furthermore, it was shown that this molecule binds to the minor groove of DNA just like a known minor groove binder, DAPI (4′,6‐diamidino‐2‐phenylindole).

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