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Synthesis and DNA‐Binding Studies of A New Cyclic Dimeric Symmetrical Pseudo‐Turn Mimetic
Author(s) -
Banerji Biswadip,
Chatterjee Satadru,
Killi Sunil Kumar,
Srinivas D.,
Prodhan Chandraday,
Katarkar Atul,
Chaudhuri Keya
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201703062
Subject(s) - intramolecular force , minor groove , turn (biochemistry) , chemistry , dna , stereochemistry , groove (engineering) , dapi , molecule , hydrogen bond , crystallography , materials science , biochemistry , organic chemistry , apoptosis , metallurgy
A new dimeric cyclic 24 member symmetrical turn analogue was synthesized efficiently by an intramolecular Heck reaction. This facile reaction has produced selectively a single dimeric product having two sets of intramolecular hydrogen bonds (IHB) at the two ends of it. Different experimental studies have unambiguously proved the presence of a pseudo‐turn like structure. Furthermore, it was shown that this molecule binds to the minor groove of DNA just like a known minor groove binder, DAPI (4′,6‐diamidino‐2‐phenylindole).