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Selective Inhibition of Enterovirus A Species Members’ Reproduction by Furano[2, 3‐ d ]pyrimidine Nucleosides Revealed by Antiviral Activity Profiling against (+)ssRNA Viruses
Author(s) -
Kozlovskaya Liubov I.,
Golinets Anastasia D.,
Eletskaya Anastasia A.,
Orlov Alexey A.,
Palyulin Vladimir A.,
Kochetkov Sergey N.,
Alexandrova Liudmila A.,
Osolodkin Dmitry I.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201703052
Subject(s) - pyrimidine , virology , enterovirus , flavivirus , encephalitis , biology , virus , nucleoside , enterovirus 71 , viral replication , purine , uridine , antiviral drug , chemistry , rna , biochemistry , enzyme , gene
The rational design of broad‐spectrum antivirals requires data on antiviral activity of compounds against multiple viruses, which are often not available. We have developed a panel of (+)ssRNA viruses composed of Enterovirus and Flavivirus genera members allowing to study these activity spectra. Antiviral activity profiling of a set of nucleoside analogues revealed N 4 ‐hydroxycytidine as an efficient inhibitor of replication of coxsackieviruses and other enteroviruses, but ineffective against tick‐borne encephalitis virus. Furano[2, 3‐ d ]pyrimidine nucleosides with n ‐pentyl or n ‐hexyl tails showed selective inhibition of Enterovirus A representatives. 5‐(Tetradec‐1‐yn‐1‐yl)‐uridine showed selective inhibition of tick‐borne encephalitis virus at the micromolar level.