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A Practical and Efficient Stereoselective Synthesis of (S)‐Rivastigmine and (R)‐Rivastigmine
Author(s) -
Hua YongGang,
Han LanPing,
Yang QianQian,
Wang MeiJing,
Zhang En,
Liu HongMin
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201703032
Subject(s) - rivastigmine , stereoselectivity , chemistry , amination , alcohol , organic chemistry , catalysis , medicine , dementia , disease , pathology , donepezil
A stereoselective synthesis of (S)‐rivastigmine and (R)‐rivastigmine was developed. The key steps were stereoselective chlorination of a chiral secondary benzylic alcohol intermediate and amination of the corresponding chloride. Based on this method, both stereoisomers of rivastigmine were obtained stereoselectively in high yields.