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Citric‐Acid‐Catalyzed Green and Sustainable Synthesis of Novel Functionalized Pyrano[2, 3‐ e ]pyrimidin‐ and Pyrano[2, 3‐ d ]pyrazol‐amines in Water via One‐Pot Multicomponent Approaches
Author(s) -
Govindaraju Santhosh,
Tabassum Sumaiya,
Pasha Mohamed Afzal
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201703023
Subject(s) - citric acid , chemistry , catalysis , green chemistry , aqueous medium , environmentally friendly , aqueous solution , reaction conditions , combinatorial chemistry , organic chemistry , reaction mechanism , ecology , biology
Abstract An efficient entry into the preparation of elusive, novel pyrano[2, 3‐ e ]pyrimidin‐amines and pyrano[2, 3‐ d ]pyrazol‐amines has been accomplished using citric acid as a green catalyst in aqueous medium at 25 °C. The strategy successively tolerates a variety of functional groups and interestingly, it is eco‐compatible, environment‐friendly, propitious and the products are obtained in excellent yields without chromatographic purification. The current methodology unfolds the benefits of citric acid as an effective, expeditious, economical, green catalyst and thus adheres to the principles of green chemistry. Ecstatically, the reaction was scaled to the gram level ascertaining the wide applicability of the protocol in academia and industry. The green metrics (E‐factor: 0.0497, Mass intensity: 1.1022, PMI: 1.0497 and E mw : 0.0497) for the reaction was also envisaged and the pathway was found to acquaint excellent green chemistry metrics.