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Synthesis and Immobilization of Benzothiazole‐Appended Triazole‐Silane: Biological Evaluation and Molecular Docking Approach
Author(s) -
Singh Gurjaspreet,
Chowdhary Kavita,
Satija Pinky,
Singh Akshpreet,
Singh Baljinder,
Singh Kashmir,
Espinosa Cristóbal,
Esteban M. Angeles,
Sehgal Rakesh,
Verma Vikas
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201703017
Subject(s) - benzothiazole , silane , chemistry , docking (animal) , adsorption , combinatorial chemistry , triazole , vibrio cholerae , click chemistry , nuclear chemistry , organic chemistry , bacteria , biology , medicine , nursing , genetics
The present work involves the synthesis of Benzothiazole capped triazole‐silane (3) by ‘Click Silylation’ and its immobilization onto silica surface. This new silane is characterised by IR, 1H, 13C spectroscopy. TGA, TEM and SEM were the evidence for its adsorption at silica surface. The anti‐parasitic, anti bacterial and anti oxidant activity of synthesised compounds was evaluated. The results shows that nanoparticle of silane displayed more significant activity as compared to benzothiazole derived silane (3) against G. lamblia, T. vaginalis, various bacterial strains (E.coli, Bacillus subtillus, Staphylococcus aureus, Vibrio cholera) and showed potential anti‐oxidant activity. Further Molecular docking study was performed to analyse the binding manner and enzyme inhibitory activity of compound‐ 3 with β‐glucuronidase.