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Three Regioselectively Acylated Flavonoid Aglycone Derivatives in Equimolar Yield at One Blow
Author(s) -
Kyriakou Eleni,
Kostagianni Androniki D.,
Kellici Tahsin F.,
Giannopoulou Efstathia,
Siatis Konstantinos E.,
Sayyad Nisar,
Kalofonos Haralabos P.,
Mavromoustakos Thomas,
Stamatis Haralambos,
Tzakos Andreas G.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201703002
Subject(s) - aglycone , regioselectivity , flavonoid , quercetin , chemistry , yield (engineering) , potency , combinatorial chemistry , stereochemistry , biochemistry , in vitro , materials science , catalysis , glycoside , metallurgy , antioxidant
A simple and time‐effective chemoenzymatic process to obtain three regioselective acylated quercetin analogues in a 1:1:1 ratio in one pot is described. This process overcomes the inherent scaffold intricacy and synthetic complexity of quercetin. Cell proliferation experiments in three breast cancers cell lines pinpoint the high potency of the generated compounds.