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Aerosil‐Supported Ionic‐Liquid‐Phase (ASILP) Mediated Synthesis of 2‐Substituted Benzimidazole Derivatives as AChE Inhibitors
Author(s) -
Sonawane Babasaheb D.,
Rashinkar Gajanan S.,
Sonawane Kailas D.,
Dhanavade Maruti J.,
Sonawane Vikas D.,
Patil Suresh V.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702969
Subject(s) - ionic liquid , benzimidazole , chemistry , fumed silica , catalysis , aché , adsorption , combinatorial chemistry , docking (animal) , organic chemistry , enzyme , acetylcholinesterase , medicine , nursing
Aerosil supported ionic liquid phase (ASILP) has been prepared by confinement of ionic liquid [Bmim]PF 6 on the aerosil support by adsorption interactions. This novel ASILP served as robust heterogeneous catalyst in the synthesis of biologically relevant 2‐substituted benzimidazoles from o ‐phenylenediamines and aryl aldehydes in high yields under mild reaction conditions. The molecular docking studies revealed potential of 2‐substituted benzimidazoles to act as acetyl cholinesterase inhibitors (AChE).