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Promiscuity of Lipase‐Catalyzed Reactions for Organic Synthesis: A Recent Update
Author(s) -
Dwivedee Bharat P.,
Soni Surbhi,
Sharma Misha,
Bhaumik Jayeeta,
Laha Joydev K.,
Banerjee Uttam C.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702954
Subject(s) - lipase , kinetic resolution , knoevenagel condensation , biocatalysis , chemistry , organic chemistry , catalysis , organic synthesis , condensation reaction , enantiopure drug , organic reaction , transesterification , combinatorial chemistry , enantioselective synthesis , reaction mechanism , enzyme
Lipase‐catalyzed organic reactions have widely been practiced in the past three decades. In addition to its wide acceptance in conventional reactions such as hydrolysis, transesterification, and enantiopure synthesis (kinetic resolution and dynamic kinetic resolution) several reports on the catalytic promiscuity of lipases have also been published. The concept of promiscuity, where lipase catalyzes reactions beyond its natural function, has been perceived as a useful phenomenon which can enhance the utility of lipase as a biocatalyst. Many useful organic reactions such as Aldol condensation, Hantzsch reaction, Canizzaro reaction, Mannich reaction, Baylis‐Hillman reaction, Knoevenagel condensation, Michael addition, Ugi reaction, and oxidation catalyzed by lipases have surfaced in the literature. The current review is a critical compilation of such research findings to put forth the synthetic applications of lipase, beyond the orthodox biocatalytic toolbox.