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Supramolecular Complexation of Biologically Important Thioflavin‐T with p‐Sulfonatocalix[4]arene
Author(s) -
Saravanan Chokalingam,
Ashwin Bosco Christin Maria Arputham,
Senthilkumaran Marimuthu,
Mareeswaran Paulpandian Muthu
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702937
Subject(s) - thioflavin , chemistry , supramolecular chemistry , crystallography , molecule , nuclear magnetic resonance spectroscopy , spectroscopy , nuclear overhauser effect , two dimensional nuclear magnetic resonance spectroscopy , proton nmr , infrared spectroscopy , stereochemistry , organic chemistry , crystal structure , medicine , physics , disease , pathology , quantum mechanics , alzheimer's disease
The inclusion of thioflavin T (ThT) with p‐sulfonatocalix[4]arene (p‐SC4) is briefly discussed in solution as well as solid state. The restricted rotation of C−C single bond between indole and benzene ring system is the reason for emission property of ThT. The encapsulation of ThT using a flexible charged host molecule exploit the correlation between the C−C single bond rotation and emission enhancement. The binding of ThT with p ‐SC4 in solution state is studied using absorption, emission, electrochemical, 1 H NMR and rotating frame nuclear overhauser effect spectroscopy (ROESY) techniques. A stable water insoluble supramolecular complex is synthesized from water soluble ThT and p‐SC4. The structural features of the prepared solid complex is established from infrared (FT‐IR), powder X‐ray diffraction (XRD), Mass, 1 H NMR and nuclear overhauser effect spectroscopy (NOESY) analyses.