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Water‐Mediated One‐Pot Three‐Component Reaction to Bifunctionalized Thiadiazoloquinazolinone‐coumarin Hybrids: A Green Approach
Author(s) -
Wadhwa Preeti,
Kharbanda Anupreet,
Bagchi Sourav,
Sharma Anuj
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702908
Subject(s) - bifunctional , coumarin , microwave irradiation , environmentally friendly , catalysis , solvent , component (thermodynamics) , microwave , aryl , chemistry , organic chemistry , combinatorial chemistry , computer science , physics , thermodynamics , biology , ecology , telecommunications , alkyl
A facile, eco‐friendly protocol has been developed for synthesis of novel bifunctional coumarin‐thiadiazoloquinazolinone containing heterocycles via one pot, three component reaction of 5‐aryl‐1,3,4‐thiadiazol‐2‐amines, 1,3‐dicarbonyls and 2‐oxo‐2 H ‐chromene‐3‐carbaldehyde under microwave irradiation in water. Characteristics of the method include the use of environmentally benign solvent and catalyst, mild reaction conditions, moderate to high yields of products and the applicability of microwave irradiation as a source of energy.