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2‐Formylarylsulfonate from Aryne: A Sequential Reaction Strategy for Direct Synthesis of ortho ‐Hydroxyl‐Protected Aryl Aldehydes
Author(s) -
Sharma Abhilash,
Gogoi Pranjal
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702896
Subject(s) - aryne , chemistry , bond cleavage , aryl , yield (engineering) , combinatorial chemistry , reaction conditions , organic synthesis , organic chemistry , catalysis , materials science , alkyl , metallurgy
Abstract A novel transition‐metal free synthetic strategy has been developed for the direct synthesis of 2‐formylarylsulphonate from aryne precursor. The reaction proceeds via CO and C−C bond cleavage as well as C−O,C−C and O−S bond formations in a single reaction vessel. The methodology provides good yield of 2‐formylarylsulphonates and tolerates variety of functional groups. The strategy opens a new avenue for the direct synthesis of ortho ‐hydroxyl‐protected aryl aldehydes in organic synthesis.