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Catalyst Free Selective Monobenzoylation of Diols with Benzoyl Cyanide: A Robust and Regioselective Strategy
Author(s) -
Waseem Malik Abdul,
Lone Ali Mohd,
Teli Bisma,
Bhat Bilal A.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702893
Subject(s) - regioselectivity , catalysis , cyanide , chemistry , adduct , combinatorial chemistry , organic chemistry , reaction conditions
Abstract A general and robust strategy for regio‐ and chemoselective benzoylation of diols and polyols was developed under catalyst‐free reaction conditions. This approach is highly flexible in generating a diverse range of 1,2‐, 1,3‐, and 1,4‐monobenzoylated‐adducts in excellent yields without the involvement of expensive catalysts. Collectively, these results have implications in reducing the burden of cost and toxicity associated with the catalysts used in earlier methods.