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Copper‐Catalyzed Sonogashira Reaction in Water
Author(s) -
Liu Yujia,
Blanchard Vincent,
Danoun Grégory,
Zhang Zhaoyang,
Tlili Anis,
Zhang Wenlong,
Monnier Florian,
Van Der Lee Arie,
Mao Jincheng,
Taillefer Marc
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702854
Subject(s) - sonogashira coupling , copper , acetylide , moiety , catalysis , chemistry , combinatorial chemistry , photochemistry , inorganic chemistry , organic chemistry , palladium
Copper‐catalyzed Sonogashira reaction has been realized under biphasic conditions (water / organic substrates) allowing decreasing the copper loading up to 0.02–0.2 mol %. A potential intermediate species of the reaction, corresponding to a copper cluster linked with acetylide moiety, has been identified.