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Copper‐Catalyzed Reduction of Azides with Hydrosilanes
Author(s) -
Chen Yang,
Yang Lixin,
Zhang Xiao,
Deng Shengqi,
You Li,
Liu Yu
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702802
Subject(s) - catalysis , chemistry , copper , reduction (mathematics) , reducing agent , functional group , combinatorial chemistry , selective catalytic reduction , reaction conditions , organic chemistry , medicinal chemistry , geometry , mathematics , polymer
Abstract The copper‐catalyzed reduction of azides by reaction with hydrosilanes is reported. The most efficient CuCl/IPr ⋅ HCl (IPr=N,N′‐bis‐(2,6‐diisopropylphenyl)imidazol‐2‐ylidene) catalytic system by employing (EtO) 3 SiH as the reducing agent has been developed. Diverse amines and primary amides are obtained in moderate to excellent yields with high functional group tolerance under very mild conditions.