Copper‐Catalyzed Reduction of Azides with Hydrosilanes | Zendy

Chen Yang | Zendy; Yang Lixin | Zendy; Zhang Xiao | Zendy; Deng Shengqi | Zendy; You Li | Zendy; Liu Yu | Zendy

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Copper‐Catalyzed Reduction of Azides with Hydrosilanes

Author(s) -

Chen Yang,

Yang Lixin,

Zhang Xiao,

Deng Shengqi,

You Li,

Liu Yu

Publication year - 2018

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201702802

Subject(s) - catalysis , chemistry , copper , reduction (mathematics) , reducing agent , functional group , combinatorial chemistry , selective catalytic reduction , reaction conditions , organic chemistry , medicinal chemistry , geometry , mathematics , polymer

The copper‐catalyzed reduction of azides by reaction with hydrosilanes is reported. The most efficient CuCl/IPr ⋅ HCl (IPr=N,N′‐bis‐(2,6‐diisopropylphenyl)imidazol‐2‐ylidene) catalytic system by employing (EtO) 3 SiH as the reducing agent has been developed. Diverse amines and primary amides are obtained in moderate to excellent yields with high functional group tolerance under very mild conditions.

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