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Sonogashira Reaction: Synthesis of Novel Derivatives of 3‐Aryl‐Substituted 6‐Chloroimidazo[2, 1‐a]phthalazines Catalyzed by Pd‐Cu in Water
Author(s) -
Bakherad Mohammad,
Karami Saeed,
Keivanloo Ali
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702757
Subject(s) - aryl , potassium carbonate , catalysis , sonogashira coupling , chemistry , halide , potassium , base (topology) , proton nmr , combinatorial chemistry , medicinal chemistry , palladium , organic chemistry , mathematical analysis , alkyl , mathematics
The reaction of 1‐chloro‐4‐propargylaminophthalazine with various aryl halides catalyzed by Pd−Cu in the presence of potassium carbonate, as the base, in water leads to the one‐pot formation of new derivatives of 3‐aryl‐substituted‐6‐chloroimidazo‐[2, 1‐ a ]phthalazines in moderate‐to‐good yields. Their structures are confirmed by IR and NMR spectra as well as elemental analyses. All the compounds prepared are screened in vitro for their anti‐bacterial activities. The preliminary results indicate that some target compounds exhibit promising anti‐bacterial potency.