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Use of Glycosyl Dithiocarbamates: Small Molecule ‘Turn‐on’ Fluorescent Probe for Carbohydrate Binding Proteins
Author(s) -
Das Rituparna,
Mishra Bedangshu,
Mukhopadhyay Balaram
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702683
Subject(s) - fluorescence , chemistry , glycosyl , turn (biochemistry) , lectin , carbohydrate , molecular probe , derivative (finance) , fluorophore , galactose , yield (engineering) , biochemistry , combinatorial chemistry , dna , physics , materials science , quantum mechanics , financial economics , economics , metallurgy
A glycosyl dithiocarbamate derivative is developed as a “turn on” fluorescent sensor for lectins. The probe is prepared through a three‐component reaction in good yield and fully characterized by analytical experiments. Upon interaction with lectin ConA, the virtually non‐fluorescent probe has shown “turn on” sensing with absolute specificity in terms of the carbohydrate used, mannose in this particular case. The probe with galactose remained inactive with ConA. The simple and general strategy for the synthesis of this particular probe offers the scope for multiple probes by altering the carbohydrate moiety and thus, opens up the avenue to target various lectin sensing.