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A Facile Room Temperature Synthesis of Large Silver Nanoplates with Low Cytotoxicity
Author(s) -
Shahzad Aasim,
Chung Jiyong,
Lee TaeJin,
Kim Yeong Hwan,
Bhang Suk Ho,
Kim WooSik,
Yu Taekyung
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702661
Subject(s) - cytotoxicity , hydrogen peroxide , aqueous solution , nanoparticle , materials science , precipitation , silver nanoparticle , silver chloride , nanotechnology , chemical engineering , nuclear chemistry , reducing agent , chemistry , organic chemistry , in vitro , electrode , biochemistry , physics , meteorology , engineering
In this work, a simple, fast, and room temperature aqueous‐phase route was developed to synthesize highly aniotropic silver (Ag) nanoplates with controllable sizes from 1 to 17 μm. Our simple synthetic protocol involves the direct reduction of polyethyleneimine (PEI) stabilized silver chloride (AgCl) nanoparticles with hydrogen peroxide (H 2 O 2 ) in the presence of pyrrolidone in an aqueous‐phase at room temperature for short reaction time of 10 min. In the growth mechanism study, we found that the AgCl nanoparticles (seeds) were formed by the precipitation reaction of AgNO 3 with NaCl in the presence of PEI at the early stage, and after the addition of H 2 O 2 , Ag + in AgCl was reduced to Ag 0 , making small Ag nanoparticles. Then large Ag nanoplates were formed by attachment and fusion of the small Ag nanoparticles. Cytotoxicity of Ag nanoplates was tested with by human adipose derived stem cells. Ag nanoplates showed no cytotoxicity upto 50 μM/ml while 5 μM/ml of Ag nanoparticles treatment showed high cytotoxicity. Also Ag nanoplates treated cells showed reduced pro‐apoptotic gene expressions copampared to Ag nanoplates treatment. This modality may lead to further bio‐application based on Ag nanoplates.