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A Green and Versatile Route to Highly Functionalized Benzofuran Derivatives Using Biomimetic Oxygenation
Author(s) -
Rebelo Susana L. H.,
Pires Sónia M. G.,
Simões Mário M. Q.,
Medforth Craig J.,
Cavaleiro José A. S.,
Neves M. Graça P. M. S.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702643
Subject(s) - benzofuran , furan , chemistry , reactivity (psychology) , combinatorial chemistry , benzene , natural product , ring (chemistry) , catalysis , organic chemistry , medicine , alternative medicine , pathology
One‐pot green reactions useful for the synthesis of novel and potentially biologically active compounds have been developed using metaloporphyrin catalyzed oxidations of benzofurans. Minor variations of the reaction parameters allow direction of the reactivity (furan versus benzene ring) and the production of multifunctional 2,3‐dihydrobenzofurans, salicyl derivatives or an unusual dimerization product. These studies suggest pathways for the metabolic oxidation and activation of pharmaceuticals and other molecules containing the benzofuran core.