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Unprecedented Synthesis of 2‐Aminochromones and 2‐Aminoquinolones through an Electrophilic C– Cyanation and 6‐ exo ‐dig Cyclization Cascade with the Intermediary of β‐Ketonitriles
Author(s) -
Sudhakar Kadari,
Goud Erukala Yadaiah,
Thirupathi Gogula,
Hemasri Yerrabelly,
Mahesh Kasthuri,
Raghavendar Avula,
Babu H. Sharath,
Kumar K. Shiva
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702639
Subject(s) - electrophile , domino , cyanation , dig , reagent , chemistry , cascade , combinatorial chemistry , medicinal chemistry , organic chemistry , computer science , catalysis , computer security , chromatography
For the first time, a domino electrophilic cyanation, using environmentally benign electrophilic cyanating reagent N ‐cyano‐ N ‐phenyl‐p‐toluenesulfonamide (NCTS) to form β‐ketonitriles, and 6‐ exo ‐dig cyclization were employed for the synthesis of 2‐aminochromones and 2‐aminoquinolones in very good yields. This protocol can also be regulated to get β‐ketonitriles as the products.