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Iodine‐Catalyzed Synthesis of Pyrrolo(2,3‐ c )coumarin Derivatives Using 3‐Aminocoumarins, Arylglyoxals and 4‐Hydroxycoumarin through One‐Pot Three‐Component Reaction
Author(s) -
Belal Md.,
Khan Abu T.
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702629
Subject(s) - coumarin , catalysis , 4 hydroxycoumarin , chemistry , iodine , combinatorial chemistry , reaction conditions , aqueous solution , component (thermodynamics) , organic chemistry , physics , thermodynamics
Abstract Synthesis of pyrrolo(2,3‐ c )coumarin derivatives was achieved from 3‐aminocoumarins, arylglyoxals and 4‐hydroxycoumarin using 20 mol% molecular iodine as a catalyst through one‐pot three‐component reaction. The products were isolated without aqueous work‐up or column chromatography in good yields. The present protocol is an efficient synthetic route to access various substituted pyrrolo(2,3‐ c )coumarin derivatives in large scale.