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Concise Synthesis of the Phosphoglycerylated Tetrasaccharide Repeating Unit of the Capsular Polysaccharide of Streptococcus pneumoniae Serotype 11 A
Author(s) -
Si Anshupriya,
Misra Anup Kumar
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702500
Subject(s) - tetrasaccharide , polysaccharide , glycosylation , stereochemistry , yield (engineering) , derivative (finance) , streptococcus pneumoniae , stereoselectivity , chemistry , biochemistry , materials science , catalysis , antibiotics , economics , financial economics , metallurgy
A concise convergent synthetic strategy has been developed for the first synthesis of the glycerol phosphate‐containing tetrasaccharide repeating unit of the capsular polysaccharide of S. pneumoniae 11 A strain in very good yield. A stereoselective [2+2] block glycosylation strategy has been adopted for the synthesis of the tetrasaccharide derivative. All glycosylations were highly stereoselective with satisfactory yield.