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Choline Azide: New Reagent and Ionic Liquid in Catalyst‐Free and Solvent‐Free Synthesis of 5‐Substituted‐1 H ‐Tetrazoles: A Triple Function Reagent
Author(s) -
Mehraban Jamshid Azarnia,
Azizi Kobra,
Jalali Mahsa Sadat,
Heydari Akbar
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702427
Subject(s) - reagent , azide , ionic liquid , catalysis , chemistry , combinatorial chemistry , choline , solvent , yield (engineering) , green chemistry , organic chemistry , materials science , biochemistry , metallurgy
An efficient and green route for the synthesis of 5‐substituted‐1 H ‐tetrazoles using choline azide as a new azidation reagent in solvent‐free and catalyst‐free conditions, is reported for the first time. The noteworthy aspects of this high‐yield and cost‐effective reaction are simple methodology, mild reaction conditions, easy work‐up procedure, low reaction time, and specially using choline azide as an effective alternative to hazardous azidation agent.