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Use of Nanomagnetic Sulfated Zirconia (Fe 3 O 4 @ZrO 2 /SO 4 2− ) as Sustainable Heterogeneous Acid Catalyst for Synthesis of Spiroheterocycles under Solvent‐Free Conditions
Author(s) -
Tailor Yogesh Kumar,
Khandelwal Sarita,
Gopal Ram,
Rushell Esha,
Prajapati Anamika,
Kumar Mahendra
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702422
Subject(s) - catalysis , heterogeneous catalysis , cubic zirconia , grinding , solvent , domino , materials science , isatin , microporous material , cascade reaction , chemistry , nuclear chemistry , organic chemistry , metallurgy , ceramic
An efficient and environmentally benign domino protocol has been presented for the synthesis of structurally diverse spiroheterocycles spiroannulated with 1,3,4‐thiadiazolo[3, 2‐ a ]pyrimidine involving three‐ component reaction of 2‐amino‐1,3,4‐thiadiazole, isatin/N‐methyl‐4‐piperidone/1,2‐acenaphthylenedione and carbonyl compounds catalyzed by magnetically recoverable and reusable nanocrytalline sulfated zirconia (Fe 3 O 4 @ZrO 2 /SO 4 2− ) under solvent free conditions with grinding at room temperature. The use of magnetically recyclable and reusable catalyst, mild reaction conditions with operational simplicity (grinding), and excellent product yields are significant features of the present synthetic protocol. Moreover, easy magnetic separation of the catalyst eliminates the requirement of catalyst filtration after completion of the reaction and the catalyst remains highly active even after recycled several times.