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A Catalyst‐Free Cycloaddition Reaction: Access to Spiro[chroman‐3,2’‐indene‐1’,3’‐dione] Scaffolds
Author(s) -
Han Yuzhe,
Zhu Yingzu,
Zhang Pangmiaomiao,
Li Wenjun,
Li Pengfei
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702398
Subject(s) - indane , diastereomer , cycloaddition , chemistry , indene , catalysis , combinatorial chemistry , organic chemistry , stereochemistry
We have reported herein a catalyst‐free cycloaddition of ortho ‐hydroxyphenyl‐substituted para ‐quinone methides and 2‐arylideneindane‐1,3‐diones by which a series of chromans featuring a spiro indane‐1,3‐dione scaffolds were obtained in high yields without any additives. Importantly, both anti ‐ and syn ‐ diastereomers could be obtained as single diastereomers respectively. Moverover, the current methold provides a novel and convenient approach for the efficient incorporation of the two biologically important scaffolds (chroman and spiro indane‐1,3‐dione).