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One‐Pot Heck and Reduction: Application towards Efficient Synthesis of Flavans Promoted by Lewis Acid
Author(s) -
Raishu,
Niharika Pedireddi,
Kishore Dakoju Ravi,
Satyanarayana Gedu
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702395
Subject(s) - chemistry , heck reaction , intramolecular force , lewis acids and bases , allylic rearrangement , organic chemistry , catalysis , palladium
An effective two‐step process for the synthesis of functionalized flavans is presented. The proposed route comprises one‐pot method involving Heck reaction with allylic alcohols and 2‐iodophenols followed by reduction. These diols upon treatment with the Lewis acid mediated intramolecular cyclization, under mild reaction conditions, afforded the flavans.