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Electrical Nucleotide Sensor Based on Synthetic Guanine‐Receptor‐Modified Electrodes
Author(s) -
Ohshiro Takahito,
Verma Rajiv Kumar,
Yokota Kazumichi,
Tsutsui Makusu,
Mukherjee Sanjukta,
Kawai Tomoji,
Nakatani Kazuhiko,
Taniguchi Masateru
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702341
Subject(s) - guanine , guanosine , chemistry , guanosine monophosphate , deoxyguanosine , nucleotide , electrode , polynucleotide , cyclic voltammetry , combinatorial chemistry , hydrogen bond , molecule , stereochemistry , organic chemistry , biochemistry , dna , electrochemistry , gene
Abstract Methyl 2‐carbamate‐1,8‐naphthyridine thiophenolate derivative (NCTP) has been designed and synthesized, which can selectively bind to guanine derivatives. We immobilized NCTP on gold electrode and performed cyclic voltammetry analysis for guanosine sensing. The current blockage data obtained from these NCTP immobilized electrodes suggest that electrodes have higher selectivity for 2’‐deoxyguanosine monophosphate (dGMP) than 2’‐deoxythymidine monophosphate (dTMP), 2’‐deoxycytidine monophosphate (dCMP), and 2’‐deoxyadenosine monophophate (dAMP). Thus, synthetic reader molecule NCTP, which has complementary hydrogen bonding surface for guanine derivatives, could be useful for the sensing of guanosine mononucleotides and polynucleotides.