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Catalyst Free Synthesis of Bis(Indolyl)Methanes and 3,3‐Bis(Indolyl)oxindoles in Aqueous Ethyl Lactate
Author(s) -
Gao Ge,
Han Yi,
Zhang ZhanHui
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702326
Subject(s) - catalysis , yield (engineering) , chemistry , ethyl lactate , environmentally friendly , substrate (aquarium) , organic chemistry , aqueous medium , reaction conditions , combinatorial chemistry , aqueous solution , materials science , ecology , oceanography , metallurgy , biology , geology
A highly efficient and environmentally friendly approach has been reported for the synthesis of bis(indolyl)methanes and 3,3‐bis(indolyl)oxindoles by reacting of indoles with aldehydes or isatins in water‐ethyl lactate under ultrasound irradiation. This protocol presents the benefits of catalyst‐free, operational simplicity, short reaction time, high product yield, broad substrate scope and applicability for large‐scale synthesis.