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Synthesis of Amides from Aliphatic Acids and Amines by using of I 2 /TBHP at Room Temperature
Author(s) -
Sirgamalla Rambabu,
Kommakula Ashok,
Banoth Sonyanaik,
Dharavath Ravi,
Adem Kurumanna,
P Madhu,
Boda Sakram
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702286
Subject(s) - thioglycolic acid , acetic anhydride , chemistry , acetic acid , functional group , reaction conditions , scope (computer science) , organic chemistry , combinatorial chemistry , catalysis , computer science , polymer , programming language
A novel metal free system of I 2 /TBHP for coupling of anilines with various acids leading to amidation has been developed. The reaction possibly proceeds via acetic hypoiodous anhydride formation. Besides, the scope of the method was also extended to thioglycolic acid and phenoxy acetic acids. The reaction is easy to set up, involves mild conditions and proceeds efficiently over a wide range of substrates with excellent functional group tolerance.