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Microwave‐Assisted Highly Efficient Route to 4‐Aminoquinoline‐Phthalimide Conjugates: Synthesis and Anti‐Tubercular Evaluation
Author(s) -
Rani Anu,
Viljoen Albertus,
Kremer Laurent,
Kumar Vipan
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702220
Subject(s) - phthalimides , phthalimide , microwave , combinatorial chemistry , mycobacterium tuberculosis , nuclear chemistry , microwave heating , chemistry , materials science , tuberculosis , organic chemistry , medicine , physics , quantum mechanics , pathology
Microwave assisted synthesis of 4‐aminoquinoline‐phthalimides was carried out in order to probe their anti‐tubercular potential. Different conditions were screened both under conventional and microwave heating and the best results were obtained by microwave heating in DMSO at 160 o C for 2 min affording the desired 4‐aminoquinoline‐phthalimides in quantitative yields. Anti‐tubercular evaluation against mc 2 6230 strain of Mycobacterium tuberculosis revealed 3 e, having an octyl chain length as spacer, to be the most potent of the synthesized compounds exhibiting MIC 99 of 13.7 μM.