z-logo
Premium
Visible Light‐Mediated Installation of Halogen Functionalities into Multiple Bond Systems
Author(s) -
Kim Hyun Jin,
Kim Min
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702184
Subject(s) - trifluoromethylation , halogenation , photoredox catalysis , electrophile , halogen , chemistry , context (archaeology) , organic synthesis , combinatorial chemistry , halogen bond , catalysis , regioselectivity , organic chemistry , reactivity (psychology) , photocatalysis , trifluoromethyl , alkyl , medicine , paleontology , alternative medicine , pathology , biology
Abstract Photoredox catalysis has emerged as a useful tool for organic, synthetic, and material chemists to approach target molecules with new functionalities and structural complexity. This review focuses on the recent advances in the visible light‐promoted halogenation and trifluoromethylation/difluoromethylation of multiple bonds. Halogen functionalities are important chemical handles and building blocks in organic synthesis. Both electrophilic addition of halogens and radical halogenations are widely utilized in organic synthesis to install halogen functionalities. However, harsh conditions and low regioselectivity could present challenges. Despite these concerns, recent efforts have led to obvious advances in the visible light‐promoted halogenation of multiple bonds. In this context, we address the recent achievements in the visible light‐mediated installation of different types of halogen‐containing functionalities, which include (i) halogenation of unsaturated carbon‐carbon bonds, (ii) trifluoromethylation and difluoromethylation of π‐systems, and (iii) photoredox cyclization by insertion of fluorine sources. A variety of active catalytic species in the photoredox halogenations are also discussed in terms of their unique reactivity for the future development of highly practical and efficient processes.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here