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Tandem Prins Spirocyclization for the Synthesis of 1,8‐Dioxaspiro[4.5]decane and 1,9‐Dioxaspiro[5.5]undecane Scaffolds
Author(s) -
Kummari Vijaya Babu,
Yadav Jhillu S.,
Kankaraju Marumudi,
Reddy Basi V. Subba
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702163
Subject(s) - undecane , decane , prins reaction , tandem , cascade reaction , domino , chemistry , ring (chemistry) , organic chemistry , materials science , catalysis , composite material
Abstract A domino Prins strategy has been developed for the synthesis of 1,8‐dioxaspiro[4.5]decane and 1,9‐dioxaspiro[5.5]undecane derivatives using TMSOTf under mild conditions in short reaction times. This method is applicable to a wide range of substrates and compatible with different substituents present on aromatic ring.