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Sustainable Protocol for Benzylic ‐CH 2 Oxidation with Dioxygen to Phenones Using AuNPs@ Resin Beads
Author(s) -
Sharma Anuj S,
Kaur Harjinder
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702157
Subject(s) - acetophenone , ethylbenzene , chemistry , catalysis , alkyl , alcohol oxidation , organic chemistry , selectivity , benzene , thermal stability , combinatorial chemistry
Lately, synthesis of acetophenone from alkyl substituted benzene via a selective oxidation process has become a topic of specific interest because acetophenone is an essential raw material for the production of pharmaceuticals, perfumes, alcohols, esters and aldehydes. Nanogold has emerged as an efficient catalyst for selective oxidation reactions. Herein, we present supported AuNPs (2‐5 nm) catalysed C−H oxidation of alkyl substituted benzenes with molecular oxygen as green oxidant at atmospheric pressure. Gas chromatography coupled with mass spectroscopy (GC‐MS) used for analysis of reaction mixture showed high conversion (> 98%) and high selectivity (99% ) for acetophenone with a Turn over number of 2579. The catalyst displayed good stability (thermal and chemical) and recyclability. The generality of the protocol was tested for the oxidation of a number of substituted ethylbenzene derivatives and other CH 2 bonded molecules.