Development and Application of an NMR‐Based Assay for Polyphenol Oxidases | Zendy

Li Yu | Zendy; Zafar Ayesha | Zendy; Kilmartin Paul A. | Zendy; Reynisson Jóhannes | Zendy; Leung Ivanhoe K. H. | Zendy

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Development and Application of an NMR‐Based Assay for Polyphenol Oxidases

Author(s) -

Li Yu,

Zafar Ayesha,

Kilmartin Paul A.,

Reynisson Jóhannes,

Leung Ivanhoe K. H.

Publication year - 2017

Publication title -

chemistryselect

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.437

H-Index - 34

ISSN - 2365-6549

DOI - 10.1002/slct.201702144

Subject(s) - polyphenol , polyphenol oxidase , chemistry , virtual screening , enzyme , biochemistry , tandem , combinatorial chemistry , antioxidant , drug discovery , materials science , peroxidase , composite material

Polyphenol oxidases (PPOs) are enzymes that catalyse the oxidation of phenolic compounds. We report a NMR‐based assay that can be used as a screening and validation tool for PPO activity modulators, which was demonstrated using a series of PPO inhibitors and antioxidants. This method is exemplified by work in tandem with virtual screening and molecular modelling, which led to the discovery of several novel PPO inhibitors.

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