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Base‐Promoted Substitution Reaction: A Simple, Economical, and Efficient Method for Obtaining 3‐Sulfenylated Benzo[ b ]furan Derivatives
Author(s) -
Wang Cong,
Fan Yuxin,
Yao Yaoyao,
Chen Wenzhang,
Cui Xing,
Zhu Gaofeng,
Zhou Wei,
Tang Lei
Publication year - 2018
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702142
Subject(s) - furan , chemistry , combinatorial chemistry , base (topology) , nucleophilic substitution , nucleophile , reaction conditions , organic chemistry , catalysis , mathematics , mathematical analysis
A practical and concise protocol for the efficient preparation of 3‐sulfenylated benzo[ b ]furan derivatives via an addition−elimination/vinylic‐nucleophilic substitution reaction is been described. Various substituted 3‐sulfenylated benzo[ b ]furan derivatives were synthesized in good‐to‐excellent yields under basic conditions. Remarkably, this procedure offers several advantages including good yields, mild reaction conditions, simple operation, no requirement of extra metals, and gram‐scale synthesis.