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Microwave‐Assisted Suzuki‐Miyaura Cross Coupling using Nickel as Catalyst to Rapidly Access to 3‐Arylazetidine
Author(s) -
Dequirez Geoffroy,
Bourotte Marilyne,
Porras de Francisco Esther,
Remuiñan Blanco Modesto J.,
Déprez Benoit,
Willand Nicolas
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702101
Subject(s) - nickel , catalysis , context (archaeology) , microwave irradiation , microwave , suzuki reaction , coupling (piping) , combinatorial chemistry , chemistry , materials science , organic chemistry , palladium , metallurgy , physics , paleontology , quantum mechanics , biology
Abstract The efficient synthesis of 3‐arylazetidine derivatives is reported using a Nickel‐catalyzed Suzuki‐Miyaura coupling between arylboronic acids and a N‐BOC‐protected 3‐iodoazetidine under microwave irradiation. The reaction tolerates a great range of substituents such as electrodonating and electron withdrawing groups opening the field of the diversity especially in the context of structure activity relationship studies.