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Copper‐Catalyzed ortho ‐Thiomethylation of Benzamides via 8‐Aminoquinoline‐Assisted C‐H Activation with Dimethyl Sulfoxide
Author(s) -
Cui Xinfeng,
Liu Xingxing,
Wang Xiajun,
Tian Wanfa,
Wei Daidong,
Huang Guosheng
Publication year - 2017
Publication title -
chemistryselect
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.437
H-Index - 34
ISSN - 2365-6549
DOI - 10.1002/slct.201702046
Subject(s) - dimethyl sulfoxide , chemistry , catalysis , regioselectivity , aryl , sulfoxide , functional group , copper , combinatorial chemistry , medicinal chemistry , organic chemistry , alkyl , polymer
An efficient and facile protocol concerning Cu(II)‐catalyzed methylthiolation of 8‐aminoquinoline amides under air atmosphere with widely available DMSO as the terminal thiomethyl source has been developed. The reaction exhibits excellent functional group tolerance and highly regioselectivity, which provides an attractive approach for aryl methyl thioethers preparation.